Among all the many questions about modafinil, one of the most common ones is if it can cause several diseases. It’s important to note that the FDA states that modafinil is safe to use so long as you take it as prescribed.
Increases serotonin release
Several studies have been done to evaluate modafinil’s effects on cognition. These studies have been conducted on various diseases, including attention deficit/hyperactivity disorder (ADHD), narcolepsy, multiple sclerosis, and depression. These studies show that modafinil can improve cognitive processes. However, studies have not directly compared the effects of modafinil to those of amphetamine or d-amphetamine.
Modafinil enhances the synthesis of glutamate and increases serotonin release. It also inhibits CYP 1A2, 2B6, and 2C19 enzymes. The mechanism by which modafinil inhibits these enzymes has not been determined. It is believed that modafinil may involve specific actions in the frontal cortex and may not directly affect second messenger systems.
Studies have also examined modafinil’s effects on cognitive processes in sleep-deprived mice and humans. These studies have shown that modafinil promotes wakefulness. However, it does not reduce cataplexy in humans with narcolepsy.
Taking modafinil may increase your arousal level so order modafinil. It has been dubbed the world’s best smart drug because of its dazzling effect on working and episodic memory. Taking modafinil has also been associated with a decrease in the reactivity to fear stimuli in the amygdala.
Studies have shown that modafinil increases the electrical coupling between thalamic reticular neurons. It also decreases input resistance and output resistance to GABAergic neurons. It may also increase arousal, at least in part, by acting on the PPN.
Modafinil also increases resting heart rate and resting diastolic blood pressure. These effects are mediated by dopamine and norepinephrine. These effects need to be better understood. However, modafinil has increased the P13 potential, the brain’s most prominent arousal measure. It also increases adrenomedullary discharge, a measure of adrenomedullary activation.
Reduces lethargy and fatigue
Besides sleeping well and exercising, a well-rounded diet that includes fresh fruits, vegetables and lean protein is one of the unique ways to combat fatigue. You can also pay a personal trainer to con you get the most out of your workout.
The best way to reduce your lethargy is to be well-hydrated. Make sure you drink plenty of water and consider using a pedometer to ensure you’re getting enough steps. Also, consider eating a healthy balanced diet to promote proper digestion and absorption of vital nutrients. Foods like beans, nuts and fruits are chock full of fibre, which will help stabilize your blood sugar levels.
While there’s no shortage of health gizmos and gadgets on the market, some products can help improve your well-being. These products include a vitamin B5 supplement required for fat metabolism. Other foods that are good for you include beans, nuts and seeds.
Induces cognitive dysfunction in psychiatric populations
Intensive efforts are being made to identify the causes of cognitive dysfunction in psychiatric populations. Studies have identified numerous interacting causes, including genetic, epigenetic, environmental, and developmental factors. Currently, treatment for cognitive impairment is limited. However, remediation-based therapies are under investigation.
Deficits characterize cognitive dysfunction in psychiatric populations in attention, working memory, language, and social cognition. These deficits impact real-world functioning and quality of life.
To study the relationship between cognitive dysfunction and psychopathology, the researchers used the Schizophrenia Cognition Rating Scale (SCoRS) to assess cognitive functioning. The scores ranged from 0-80, and individuals with a higher SCoRS score had more significant cognitive dysfunction.
The study examined age-related differences in cognitive performance between individuals with psychotic disorders and matched control individuals. Cognitive decline was significantly higher than expected from normal ageing. Specifically, individuals with psychotic disorders experienced a decline in cognitive functions over two decades after their first hospitalization. However, the decline was similar to those of individuals with other psychotic disorders.
Author: Dr. Ali Mazloom, graduated from the Baylor College of Medicine in 2008. He works in Cypress, TX and 3 other locations and specializes in Internal Medicine and Radiation Oncology. Dr. Mazloom is affiliated with North Cypress Medical Center.